Villarreal humbled

La Liga runners-up Villarreal were thrashed 5-0 by third-tier Poli Ejido, with Jorge Molina scoring a hat-trick for the south coast club, while Sevilla lost 1-0 to Ponferradina thanks to a 90th-minute strike from Cristian Portilla.

Earlier, Fernando Morientes netted twice as holders Valencia brushed aside modest Portugalete 4-1.

The lowest-ranked team left in the competition, lower-league side Portugalete held out for just 11 minutes before Morientes lifted a cross from Hugo Viana over the goalkeeper and into the net.

Midfielder Vicente doubled the visitors' advantage 10 minutes later, driving home a crisp left-foot shot.

Urko Vera pulled back a goal for the Basque club just after the break with a powerful header that squirmed under Guaita into the Valencia net before Viana set up Morientes for Valencia's third shortly afterwards.

Valencia poured forward as the Portugalete players tired and Nicola Zigic swept in Valencia's fourth goal shortly before the end after he was picked out by Pablo Hernandez.

Valencia, who left joint Liga top scorer David Villa out of the squad, beat Getafe 3-1 in last season's final to claim their seventh Copa del Rey.

There were four all-Liga ties in the round.

Athletic Bilbao beat visiting Recreativo 2-0 while Numancia lost 1-0 at home to Sporting Gijon and Malaga and Real Mallorca drew 1-1 in Malaga.

The match between Getafe, runners-up over the last two years, and Osasuna finishes later.

The arrival of the top-flight clubs in the tournament sees third-tier Real Union play league champions and 17-time winners Real Madrid the following day in the final first-leg tie of the round.

The previous day saw teenage striker Bojan Krkic on target to give an under-strength Barcelona a 1-0 win at Segunda B side Benidorm.

The return matches are scheduled for November 12.